Article

Tau interactome mapping reveals dynamic processes in synapses and mitochondria associated with neurodegenerative disease

2021-06-17

Abstract excerpt

<h4>SUMMARY</h4> Tau (MAPT) drives neuronal dysfunction in Alzheimer’s disease (AD) and other tauopathies. To dissect the underlying mechanisms, we combined an engineered ascorbic acid peroxidase (APEX) approach with quantitative affinity purification mass spectrometry (AP-MS) followed by proximity ligation assay (PLA) to characterize Tau interactomes modified by neuronal activity and mutations that cause frontot...

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Literature Corpus work: d1250175-0aaa-5779-b6ba-1b5b3b070cae
DOI: 10.1101/2021.06.17.448349

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