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Article

Phosphorylated tau interactome in the human Alzheimer’s disease brain

23 Jun 2020

Abstract excerpt

Accumulation of phosphorylated tau is a key pathological feature of Alzheimer's disease. Phosphorylated tau accumulation causes synaptic impairment, neuronal dysfunction and formation of neurofibrillary tangles. The pathological actions of phosphorylated tau are mediated by surrounding neuronal proteins; however, a comprehensive understanding of the proteins that phosphorylated tau interacts with in Alzheimer's...

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PMID: 32812023
DOI: 10.1093/brain/awaa223

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