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Comparative profiling of the synaptic proteome from Alzheimer’s disease patients with focus on the APOE genotype

1 Dec 2019

Abstract excerpt

Degeneration of synapses in Alzheimer's disease (AD) strongly correlates with cognitive decline, and synaptic pathology contributes to disease pathophysiology. We recently observed that the strongest genetic risk factor for sporadic AD, apolipoprotein E epsilon 4 (APOE4), is associated with exacerbated synapse loss and synaptic accumulation of oligomeric amyloid beta in human AD brain. To begin to understand the...

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PMID: 31862015
DOI: 10.1186/s40478-019-0847-7

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