Article

Complex HPV-human DNA structures revealed by large-scale DNA analyses in an HPV-cancer derived cell line

2025-10-06

Abstract excerpt

<h4>ABSTRACT</h4> Most human papillomavirus (HPV)-associated cancers harbor viral DNA integrated into the human genome as extrachromosomal circles, intrachromosomal segments, or both. Distinguishing intrachromosomal from identical-sequence extrachromosomal DNA (ecDNA) by sequencing alone is challenging, and the architecture of large-scale HPV-human DNA structures remains incompletely understood. To address this,...

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Literature Corpus work: c4d48984-53dd-5aa9-ae4c-1e3bc71ad484
DOI: 10.1101/2025.10.06.680684

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