Article

Diverse tumorigenic consequences of human papillomavirus integration in primary oropharyngeal cancers

2021-06-21

Abstract excerpt

<h4>SUMMARY</h4> Human papillomavirus (HPV) causes 5% of all cancers and frequently integrates into host chromosomes, but the impacts of integration in tumorigenesis remain unclear. Analysis of 105 HPV-positive oropharyngeal cancers by whole genome sequencing detects viral integration in 77%, revealing five statistically significant integration hotspots near genes that regulate epithelial stem cell maintenance (i...

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Literature Corpus work: b695ec21-4f5e-5c64-b45d-b5fa5881bc9e
DOI: 10.1101/2021.06.20.449168

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