Article

Extrachromosomal Amplification of Human Papillomavirus Episomes as a Mechanism of Cervical Carcinogenesis

2021-10-24

Abstract excerpt

<h4>Summary</h4> Integration of Human Papillomaviruses (HPV) is an important mechanism of carcinogenesis but is absent in a significant fraction of HPV16+ tumors. We applied long-read whole-genome sequencing (WGS) to cervical cancer cell lines and tumors. In two HPV16+ cell lines, we identified large tandem arrays of full-length and truncated viral genomes integrated into multiple locations indicating formation a...

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Literature Corpus work: f6be5ec9-ab38-5b66-887d-77d423cce096
DOI: 10.1101/2021.10.22.465367

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