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Human papillomavirus genome integration in squamous carcinogenesis: what have next‐generation sequencing studies taught us?

14 Feb 2018

Abstract excerpt

Human papillomavirus (HPV) infection is associated with ∼5% of all human cancers, including a range of squamous cell carcinomas. Persistent infection by high-risk HPVs (HRHPVs) is associated with the integration of virus genomes (which are usually stably maintained as extrachromosomal episomes) into host chromosomes. Although HRHPV integration rates differ across human sites of infection, this process appears to...

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PMID: 29443391
DOI: 10.1002/path.5058

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