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Intratumoral Heterogeneity and Clonal Evolution Induced by HPV Integration

30 Jan 2023

Abstract excerpt

The human papillomavirus (HPV) genome is integrated into host DNA in most HPV-positive cancers, but the consequences for chromosomal integrity are unknown. Continuous long-read sequencing of oropharyngeal cancers and cancer cell lines identified a previously undescribed form of structural variation, "heterocateny," characterized by diverse, interrelated, and repetitive patterns of concatemerized virus and host...

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PMID: 36715691
DOI: 10.1158/2159-8290.cd-22-0900

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