Article

Molecular mechanisms and diagnostic innovations in HPV-associated head and neck squamous cell carcinomas: Insights into integration, epigenetic modifications, and biomarker applications

2024-12-27

Abstract excerpt

• HPV is a major cause of head and neck cancers, particularly oropharyngeal cancer. • HPV integration into the host genome drives cancer development. • HPV integration induces epigenetic changes, including hypomethylation and hypermethylation. • Blood and saliva biomarkers like ctHPVDNA and HPV E6 antibodies aid in diagnosis. • Emerging technologies like NGS, liquid biopsy, and CRISPR enhance diagnosis and managem...

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Literature Corpus work: 5cd7d8d5-85bf-5ad6-a5b6-8cd3c759e833
DOI: 10.1016/j.oor.2024.100710

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