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HPV Integration Can Drive the Formation of Virus–Host Extrachromosomal DNA in Tumors

3 Apr 2023

Abstract excerpt

Human papillomavirus (HPV)-positive cancer cells contain virus and host DNA and exhibit marked genome instability. In this issue of Cancer Discovery, Akagi and colleagues characterize the remarkably complex landscape of virus-host DNA molecules in HPV-positive cells, providing evidence for diverse integrated and extrachromosomal virus-host hybrid DNAs with the potential to drive clonal evolution. See related...

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PMID: 37009703
DOI: 10.1158/2159-8290.cd-23-0097

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