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Long-read sequencing unveils high-resolution HPV integration and its oncogenic progression in cervical cancer

10 May 2022

Abstract excerpt

Integration of human papillomavirus (HPV) DNA into the human genome is considered as a key event in cervical carcinogenesis. Here, we perform comprehensive characterization of large-range virus-human integration events in 16 HPV16-positive cervical tumors using the Nanopore long-read sequencing technology. Four distinct integration types characterized by the integrated HPV DNA segments are identified with Type B...

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Cancer-related molecular mechanisms research
Cervical Cancer and HPV Research
Plant Disease Resistance and Genetics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 35538075
DOI: 10.1038/s41467-022-30190-1

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