Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Extrachromosomal Amplification of Human Papillomavirus Episomes Is a Mechanism of Cervical Carcinogenesis

27 Mar 2023

Abstract excerpt

Abstract HPV16 is the most oncogenic type of human papillomaviruses (HPV). Integration of HPV into the human genome is an important mechanism of carcinogenesis but is absent in at least 30% of HPV16+ tumors. We applied long-read whole-genome sequencing (WGS) to cervical cancer cell lines and tumors to characterize HPV16 carcinogenesis in the absence of integration. Large tandem arrays of full-length and unique...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cervical Cancer and HPV Research
Share to Molecular Biology Techniques and Applications
Share to Plant Disease Resistance and Genetics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36971511
DOI: 10.1158/0008-5472.can-22-3030

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Extrachromosomal Amplification of Human Papillomavirus Episomes Is a Mechanism of Cervical CarcinogenesisPMID 36971511Read ↗

Extrachromosomal Amplification of Human Papillomavirus Episomes as a Mechanism of Cervical CarcinogenesisSemantic proximity Read ↗

Long-read sequencing unveils high-resolution HPV integration and its oncogenic progression in cervical cancerSemantic proximity Read ↗

Human papillomavirus genome integration in squamous carcinogenesis: what have next‐generation sequencing studies taught us?Semantic proximity Read ↗

In vitro Progression of Human Papillomavirus 16 Episome-Associated Cervical Neoplasia Displays Fundamental Similarities to Integrant-Associated CarcinogenesisSemantic proximity Read ↗

Mechanistic signatures of HPV insertions in cervical carcinomasSemantic proximity Read ↗

Human Papillomavirus Integration Strictly Correlates with Global Genome Instability in Head and Neck CancerSemantic proximity Read ↗

Complex HPV-human DNA structures revealed by large-scale DNA analyses in an HPV-cancer derived cell lineSemantic proximity Read ↗

Intratumoral Heterogeneity and Clonal Evolution Induced by HPV IntegrationSemantic proximity Read ↗

Analysis of HPV Integrations in Mexican Pre-Tumoral Cervical Lesions Reveal Centromere-Enriched Breakpoints and Abundant Unspecific HPV Regions.Semantic proximity Read ↗

Multiple HPV integration mode in the cell lines based on long-reads sequencingSemantic proximity Read ↗

Intratumoral heterogeneity and clonal evolution induced by HPV integrationSemantic proximity Read ↗

Analysis of The Cancer Genome Atlas sequencing data reveals novel properties of the human papillomavirus 16 genome in head and neck squamous cell carcinomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.