Rearrangements of viral and human genomes at human papillomavirus integration events and their allele-specific impacts on cancer genome regulation.

doi:10.1101/gr.279041.124

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Rearrangements of viral and human genomes at human papillomavirus integration events and their allele-specific impacts on cancer genome regulation.

Genome research - 14 Apr 2025

Porter Vanessa L, Ng Michelle, O'Neill Kieran, MacLennan Signe, Corbett Richard D, Culibrk Luka, Hamadeh Zeid, Iden Marissa, Schmidt Rachel, Tsaih Shirng-Wern, Nakisige Carolyn, Origa Martin, Orem Jackson, Chang Glenn, Fan Jeremy, Nip Ka Ming, Akbari Vahid, Chan Simon K, Hopkins James, Moore Richard A, Chuah Eric, Mungall Karen L, Mungall Andrew J, Birol Inanc, Jones Steven J M, Rader Janet S, Marra Marco A

Abstract excerpt

Human papillomavirus (HPV) integration has been implicated in transforming HPV infection into cancer. To resolve genome dysregulation associated with HPV integration, we performed Oxford Nanopore Technologies long-read sequencing on 72 cervical cancer genomes from a Ugandan data set that was previously characterized using short-read sequencing. We find recurrent structural rearrangement patterns at HPV...

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Identifiers

PMID: 39638560
DOI: 10.1101/gr.279041.124
PMCID: PMC12047271

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