Article

Intratumoral heterogeneity and clonal evolution induced by HPV integration

2022-08-13

Abstract excerpt

<h4>ABSTRACT</h4> The human papillomavirus (HPV) genome is integrated into host DNA in most HPV-positive cancers, but the consequences for chromosomal integrity are unknown. Continuous long-read sequencing of oropharyngeal cancers and cancer cell lines revealed a unique form of structural variation, i.e., heterocateny, characterized by diverse, interrelated, and repetitive patterns of concatemerized virus and hos...

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Literature Corpus work: 95b366f7-b30c-5c1c-baf0-ef1941cc10ce
DOI: 10.1101/2022.08.11.503647

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