Article

A multi-omics integrative analysis based on CRISPR screens re-defines the pluripotency regulatory network in ESCs

2023-03-13

Abstract excerpt

<title>Abstract</title> <p>A comprehensive and precise definition of the pluripotency gene regulatory network (PGRN) is crucial for clarifying the regulatory mechanisms in embryonic stem cells (ESCs). Here, after a CRISPR/Cas9-based functional genomics screen and integrative analysis with other functional genomes, transcriptomes, proteomes and epigenome data, an expanded pluripotency-associated gene set is obtain...

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Literature Corpus work: ec6551d6-f55f-564c-8ea8-5a0d9341f6db
DOI: 10.21203/rs.3.rs-951395/v1

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