Article
Deconstructing the pluripotency gene regulatory network.
Nature cell biology - 1 Apr 2018
Li Mo, Izpisua Belmonte Juan Carlos
Abstract excerpt
Pluripotent stem cells can be isolated from embryos or derived by reprogramming. Pluripotency is stabilized by an interconnected network of pluripotency genes that cooperatively regulate gene expression. Here we describe the molecular principles of pluripotency gene function and highlight post-transcriptional controls, particularly those induced by RNA-binding proteins and alternative splicing, as an important...
Topics
- Alternative Splicing
- Animals
- Cell Differentiation
- Cellular Reprogramming
- Gene Expression Regulation, Developmental
- Gene Regulatory Networks
- Genotype
- Humans
- Phenotype
- Pluripotent Stem Cells
- RNA-Binding Proteins