Article

Lysyl oxidase regulates epithelial differentiation and barrier integrity in eosinophilic esophagitis

2023-03-28

Abstract excerpt

<h4>Background & Aims</h4> Epithelial disruption in eosinophilic esophagitis (EoE) encompasses both impaired differentiation and diminished barrier integrity. We have shown that lysyl oxidase (LOX), a collagen cross-linking enzyme, is upregulated in the esophageal epithelium in EoE. However, the functional roles of LOX in the esophageal epithelium remains unknown. <h4>Methods</h4> We investigated roles for LOX i...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c48504c3-3fb2-5191-ae1b-666084fb2560
DOI: 10.1101/2023.03.27.534387

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Lysyl oxidase regulates epithelial differentiation and barrier integrity in eosinophilic esophagitisDOI 10.1101/2023.03.27.534387Read

Suspension-Based Human Esophagoids Recapitulate WNT2B-Dependent Regulation of Esophageal Basal ProgenitorsSemantic proximity Read

In Vitro Model for Studying Esophageal Epithelial Differentiation and Allergic Inflammatory Responses Identifies Keratin Involvement in Eosinophilic EsophagitisSemantic proximity Read

FOXM1 Modulation Alleviates Epithelial Remodeling and Inflammation in Eosinophilic EsophagitisSemantic proximity Read

Interferon-γ signaling in eosinophilic esophagitis has implications for epithelial barrier function and programmed cell deathSemantic proximity Read

Modeling epithelial homeostasis and perturbation in three-dimensional human esophageal organoidsSemantic proximity Read

Esophageal epithelial cell-state transitions underlie the severity of pediatric eosinophilic esophagitisSemantic proximity Read

LOXL3 Function Beyond Amino Oxidase and Role in Pathologies, Including CancerSemantic proximity Read

LIGHT controls distinct homeostatic and inflammatory gene expression profiles in esophageal fibroblasts via differential HVEM and LTβR-mediated mechanismsSemantic proximity Read

Proteomic analysis of the esophageal epithelium reveals key features of eosinophilic esophagitis pathophysiologySemantic proximity Read

Prostaglandin E₂ Reverses Myofibroblast Differentiation in Eosinophilic EsophagitisSemantic proximity Read

Clinical heterogeneity and endotype stratification in eosinophilic esophagitis.Semantic proximity Read

Unmet therapeutic needs in eosinophilic esophagitis.Semantic proximity Read