Article

Prostaglandin E₂ Reverses Myofibroblast Differentiation in Eosinophilic Esophagitis

2026-01-29

Abstract excerpt

<h4>Background & Aims</h4> Unchecked inflammation in Eosinophilic esophagitis (EoE) leads to esophageal fibrosis and eventual stricture. Differentiated fibroblasts, termed myofibroblasts, are the main effector cells in fibrosis, responsible for secreting extracellular matrix proteins leading to tissue stiffness. Regulating myofibroblasts has not been explored as a therapeutic possibility in the fibrostenotic esop...

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Literature Corpus work: 2c98a9f4-080a-5c5e-98bd-98e1977ecc66
DOI: 10.64898/2026.01.27.702012

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