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In Vitro Model for Studying Esophageal Epithelial Differentiation and Allergic Inflammatory Responses Identifies Keratin Involvement in Eosinophilic Esophagitis

3 Jun 2015

Abstract excerpt

Epithelial differentiation is an essential physiological process that imparts mechanical strength and barrier function to squamous epithelia. Perturbation of this process can give rise to numerous human diseases, such as atopic dermatitis, in which antigenic stimuli can penetrate the weakened epithelial barrier to initiate the allergic inflammatory cascade. We recently described a simplified air-liquid interface...

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PMID: 26039063
DOI: 10.1371/journal.pone.0127755

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