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Article

LOXL3 Function Beyond Amino Oxidase and Role in Pathologies, Including Cancer

23 Jul 2019

Abstract excerpt

Lysyl oxidase like 3 (LOXL3) is a copper-dependent amine oxidase responsible for the crosslinking of collagen and elastin in the extracellular matrix. LOXL3 belongs to a family including other members: LOX, LOXL1, LOXL2, and LOXL4. Autosomal recessive mutations are rare and described in patients with Stickler syndrome, early-onset myopia and non-syndromic cleft palate. Along with an essential function in...

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PMID: 31340433
DOI: 10.3390/ijms20143587

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