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Proteomic analysis of the esophageal epithelium reveals key features of eosinophilic esophagitis pathophysiology

7 Jun 2023

Abstract excerpt

BACKGROUND: Eosinophilic esophagitis (EoE) is a chronic non-IgE-mediated allergic disease of the esophagus. An unbiased proteomics approach was performed to investigate pathophysiological changes in esophageal epithelium. Additionally, an RNAseq-based transcriptomic analysis in paired samples was also carried out. METHODS: Total proteins were purified from esophageal endoscopic biopsies in a cohort of adult EoE...

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PMID: 37287363
DOI: 10.1111/all.15779

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