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Article

Reconstruction of Contemporary Human Stem Cell Dynamics with Oscillatory Molecular Clocks

2021-03-16

Abstract excerpt

Molecular clocks record cellular ancestry. However, currently used clocks ‘tick too slowly’ to measure the short-timescale dynamics of cellular renewal in adult tissues. Here we develop ‘rapidly oscillating DNA methylation clocks’ where ongoing (de)methylation causes the clock to ‘tick-tock’ back-and-forth between methylated and unmethylated states like a pendulum. We identify oscillators using standard methylatio...

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Literature Corpus work
c4514630-275c-590c-98ae-d509766bb42f
DOI
10.1101/2021.03.15.435426
Open publication

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Reconstruction of Contemporary Human Stem Cell Dynamics with Oscillatory Molecular ClocksDOI 10.1101/2021.03.15.435426
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