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Article

The stem cell population of the human colon crypt: analysis via methylation patterns.

PLoS computational biology - 2 Mar 2007

Nicolas Pierre, Kim Kyoung-Mee, Shibata Darryl, Tavaré Simon

Abstract excerpt

The analysis of methylation patterns is a promising approach to investigate the genealogy of cell populations in an organism. In a stem cell-niche scenario, sampled methylation patterns are the stochastic outcome of a complex interplay between niche structural features such as the number of stem cells within a niche and the niche succession time, the methylation/demethylation process, and the randomness due to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17335343
DOI: 10.1371/journal.pcbi.0030028
PMCID: PMC1808490

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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