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Article

A comparison of epigenetic mitotic-like clocks for cancer risk prediction

24 Jun 2020

Abstract excerpt

BACKGROUND: DNA methylation changes that accrue in the stem cell pool of an adult tissue in line with the cumulative number of cell divisions may contribute to the observed variation in cancer risk among tissues and individuals. Thus, the construction of epigenetic "mitotic" clocks that can measure the lifetime number of stem cell divisions is of paramount interest. METHODS: Building upon a dynamic model of DNA...

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PMID: 32580750
DOI: 10.1186/s13073-020-00752-3

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