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Investigating stem cells in human colon by using methylation patterns

21 Aug 2001

Abstract excerpt

The stem cells that maintain human colon crypts are poorly characterized. To better determine stem cell numbers and how they divide, epigenetic patterns were used as cell fate markers. Methylation exhibits somatic inheritance and random changes that potentially record lifelong stem cell division histories as binary strings or tags in adjacent CpG sites. Methylation tag contents of individual crypts were sampled...

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PMID: 11517339
DOI: 10.1073/pnas.191225998

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