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Article

Age-related human small intestine methylation: evidence for stem cell niches

23 Jun 2005

Abstract excerpt

BACKGROUND: The small intestine is constructed of many crypts and villi, and mouse studies suggest that each crypt contains multiple stem cells. Very little is known about human small intestines because mouse fate mapping strategies are impractical in humans. However, it is theoretically possible that stem cell histories are inherently written within their genomes. Genomes appear to record histories (as...

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PMID: 15975143
DOI: 10.1186/1741-7015-3-10

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