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Article

Correlation of an epigenetic mitotic clock with cancer risk

3 Oct 2016

Abstract excerpt

BACKGROUND: Variation in cancer risk among somatic tissues has been attributed to variations in the underlying rate of stem cell division. For a given tissue type, variable cancer risk between individuals is thought to be influenced by extrinsic factors which modulate this rate of stem cell division. To date, no molecular mitotic clock has been developed to approximate the number of stem cell divisions in a...

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PMID: 27716309
DOI: 10.1186/s13059-016-1064-3

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