Article
Inferring human stem cell behaviour from epigenetic drift.
The Journal of pathology - 1 Jan 2009
Shibata D
Abstract excerpt
Although conventional experimental manipulations are impractical, it may be possible to infer human stem cell fates by 'reading' histories recorded within their genomes. Genomes are almost perfect copies of copies, and ancestries may be surreptitiously recorded by replication errors that inevitably accumulate. The greater the number of divisions, the greater the number of replication errors ('a molecular clock...
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