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Article

Smc5/6 maintains stalled replication forks in a recombination-competent conformation.

The EMBO journal - 21 Jan 2009

Irmisch Anja, Ampatzidou Eleni, Mizuno Ken'ichi, O'Connell Matthew J, Murray Johanne M

Abstract excerpt

The Smc5/6 structural maintenance of chromosomes complex is required for efficient homologous recombination (HR). Defects in Smc5/6 result in chromosome mis-segregation and fragmentation. By characterising two Schizosaccharomyces pombe smc6 mutants, we define two separate functions for Smc5/6 in HR. The first represents the previously described defect in processing recombination-dependent DNA intermediates when...

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Source

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Identifiers

PMID: 19158664
DOI: 10.1038/emboj.2008.273
PMCID: PMC2634738

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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