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Structural Maintenance of Chromosomes 5/6 complex dysfunction enables tumor mutagenesis

2025-12-05

Abstract excerpt

<h4>ABSTRACT</h4> The Structural Maintenance of Chromosomes (SMC) 5/6 complex is highly conserved and essential for mammalian development. SMC5/6 dysfunction in cells, model organisms, and patients with germline variants results in genome instability, though the exact function of the complex in genome maintenance remains enigmatic. Despite the importance of SMC5/6 in maintaining genome stability, the prevalence a...

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Literature Corpus work
4449ba33-09d3-587b-8c62-add44d01ced7
DOI
10.64898/2025.12.04.25341651
Open publication

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Structural Maintenance of Chromosomes 5/6 complex dysfunction enables tumor mutagenesisDOI 10.64898/2025.12.04.25341651
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