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The SMC5/6 complex prevents genotoxicity upon APOBEC3A-mediated replication stress

2023-11-28

Abstract excerpt

<h4>ABSTRACT</h4> Mutational patterns caused by APOBEC3 cytidine deaminase activity are evident throughout human cancer genomes. In particular, the APOBEC3A family member is a potent genotoxin that causes substantial DNA damage in experimental systems and human tumors. However, the mechanisms that ensure genome stability in cells with active APOBEC3A are unknown. Through an unbiased genome-wide screen, we define...

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Literature Corpus work
1d1e4cb4-31a9-5285-88d1-1956bc3539cb
DOI
10.1101/2023.11.28.568952
Open publication

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The SMC5/6 complex prevents genotoxicity upon APOBEC3A-mediated replication stressDOI 10.1101/2023.11.28.568952
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