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Article

Molecular Insights into the Architecture of the Human SMC5/6 Complex.

Journal of molecular biology - 12 Jun 2020

Adamus M, Lelkes E, Potesil D, Ganji S R, Kolesar P, Zabrady K, Zdrahal Z, Palecek J J

Abstract excerpt

A family of Structural Maintenance of Chromosome (SMC) complexes is essential for key cellular processes ensuring proper cohesion, condensation and replication. They share a common SMC-kleisin architecture allowing them to embrace DNA. In SMC5/6, the NSE1 and NSE3 KITE and NSE4 kleisin subunits form a stable subcomplex that binds DNA and regulates essential processes. In addition, NSE5 and NSE6 subunits associate...

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Identifiers

PMID: 32389690
DOI: 10.1016/j.jmb.2020.04.024

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