Article
Specialized interfaces of Smc5/6 control hinge stability and DNA association.
Nature communications - 30 Jan 2017
Alt Aaron, Dang Hung Q, Wells Owen S, Polo Luis M, Smith Matt A, McGregor Grant A, Welte Thomas, Lehmann Alan R, Pearl Laurence H, Murray Johanne M, Oliver Antony W
Abstract excerpt
The Structural Maintenance of Chromosomes (SMC) complexes: cohesin, condensin and Smc5/6 are involved in the organization of higher-order chromosome structure-which is essential for accurate chromosome duplication and segregation. Each complex is scaffolded by a specific SMC protein dimer (heterodimer in eukaryotes) held together via their hinge domains. Here we show that the Smc5/6-hinge, like those of cohesin...
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