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The SMC5/6 Complex Represses the Replicative Program of High-Risk Human Papillomavirus Type 31

25 Sept 2020

Abstract excerpt

The multi-subunit structural maintenance of chromosomes (SMC) 5/6 complex includes SMC6 and non-SMC element (NSE)3. SMC5/6 is essential for homologous recombination DNA repair and functions as an antiviral factor during hepatitis B (HBV) and herpes simplex-1 (HSV-1) viral infections. Intriguingly, SMC5/6 has been found to associate with high-risk human papillomavirus (HPV) E2 regulatory proteins, but the...

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PMID: 32992873
DOI: 10.3390/pathogens9100786

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