Article

HIF1α-glycolysis engages activation-induced cell death to drive IFN-γ induction in hypoxic T cells

2024-01-12

Abstract excerpt

<title>Abstract</title> <p>The role of HIF1α-glycolysis in regulating IFN-γ induction in hypoxic T cells is unknown. Given that hypoxia is a common feature in a wide array of pathophysiological contexts such as tumor and that IFN-γ is instrumental for protective immunity, it is of great significance to gain a clear idea on this. Combining pharmacological and genetic gain-of-function and loss-of-function approache...

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Literature Corpus work: 9cebbe3c-8ee9-5f72-9a08-08caf5c23ba7
DOI: 10.21203/rs.3.rs-3830704/v1

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