Article

Neuronal glycolytic reprogramming drives lethality via accelerated aging in a <i>Drosophila</i> model of tauopathy

2025-10-27

Abstract excerpt

<h4>ABSTRACT</h4> Neurometabolic dysfunction is a hallmark of Alzheimer’s disease (AD) and tauopathies. Whether these changes drive pathology or represent compensatory, protective responses remains unresolved. Here, we demonstrate that human tau induces Warburg-like metabolism in Drosophila neurons, characterized by coordinated upregulation of glycolytic enzymes and lactate dehydrogenase that mirrors metabolic s...

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Literature Corpus work: c417718a-6859-5142-8bde-5e4270dae6aa
DOI: 10.1101/2025.10.27.684860

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