Article

Alzheimer’s disease risk gene <i>Wwox</i> protects against amyloid pathology through metabolic reprogramming

2025-05-07

Abstract excerpt

Genome wide association studies have identified multiple loci that mediate the risk of developing late-onset Alzheimer’s Disease (LOAD). The gene WW-domain containing oxidoreductase ( WWOX ) has been identified in recent LOAD risk meta-analyses, yet its function in the brain is poorly understood. Using Drosophila, we discovered that knockdown of the highly conserved Wwox gene impacts longevity and sleep, having...

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Literature Corpus work: 27d52215-06ae-51e0-afb8-8b6e00d6376c
DOI: 10.1101/2025.05.01.651195

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