Article

Neurons undergo pathogenic metabolic reprograming in models of familial ALS

2021-08-20

Abstract excerpt

<h4>Summary</h4> Normal cellular function requires a rate of ATP production sufficient to meet demand. In most neurodegenerative diseases (including Amyotrophic Lateral Sclerosis, ALS), mitochondrial dysfunction is postulated raising the possibility of impaired ATP production and a need for compensatory maneuvers to sustain the ATP production/demand balance. We find in our rodent models of familial ALS (fALS), im...

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Literature Corpus work: b2e194c6-8010-5c37-ae14-96df27dbbe88
DOI: 10.1101/2021.08.20.457111

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