Article

Distinct forms of amyloid-β moderate sleep duration through NAD <sup>+</sup> -linked redox metabolism in Alzheimer’s disease

2025-03-03

Abstract excerpt

Sleep disruptions precede a clinical diagnosis of Alzheimer’s disease (AD) by several years. However, how AD pathologies affect sleep remains unclear. Here, we integrate epidemiological data with insights from Drosophila models of AD to investigate how AD progression could be linked to sleep disruption. We found that individuals with a high risk of AD report a shorter sleep duration than do those with a clinical...

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Literature Corpus work: ac226776-fe4f-5cfc-a2bc-c0cb969c6956
DOI: 10.1101/2025.02.26.640405

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