Article

Comparative analysis of Alzheimer’s disease knock-in model brain transcriptomes implies changes to energy metabolism as a causative pathogenic stress

2021-02-17

Abstract excerpt

<h4>Summary</h4> Energy production is the most fundamentally important cellular activity supporting all other functions, particularly in highly active organs such as brains. Here, we summarise transcriptome analyses of young adult (pre-disease) brains from a collection of eleven early-onset familial Alzheimer’s disease (EOfAD)-like and non-EOfAD-like mutations in three zebrafish genes. The one cellular activity c...

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Literature Corpus work: 7bb8b6b7-1f54-552e-8685-bb5b0d7cd09e
DOI: 10.1101/2021.02.16.431539

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