Article

Weak neuronal glycolysis sustains cognition and organismal fitness

2023-09-03

Abstract excerpt

The energy cost of neuronal activity is mainly sustained by glucose 1,2 . However, in an apparent paradox, neurons only weakly metabolize glucose through glycolysis 3,4,5,6 , a circumstance that can be accounted for by the constant degradation of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (Pfkfb3) 3,7,8 , a key glycolysis-promoting enzyme. To evaluate the in vivo physiological significance of this...

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Literature Corpus work: 46a59bd6-5308-569c-b2c6-68bf18694c05
DOI: 10.1101/2023.09.02.556016

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