A mutation in Drosophila Aldolase causes temperature-sensitive paralysis, shortened lifespan, and neurodegeneration.

Abstract excerpt

We describe the characterization of m4, an autosomal recessive, temperature-sensitive paralytic mutant in Drosophila that is associated with shortened lifespan and neurodegeneration. Deletion mapping places the mutation in the gene encoding the glycolytic enzyme, Aldolase. The mutant enzyme contains a single amino acid substitution, which results in decreased steady-state levels of Aldolase with a consequent...

Topics

• Adenosine Triphosphate
• Age Factors
• Animals
• Animals, Genetically Modified
• Cloning, Molecular
• Drosophila
• Fructose-Bisphosphate Aldolase
• Longevity
• Mutation
• Nerve Degeneration
• Neuroglia