Article

LMO7 regulates smooth muscle cell cholesterol esterification to influence plaque stability

2022-02-15

Abstract excerpt

<title>Abstract</title> <p>Smooth muscle cells (SMC) can undergo distinct fate transitions that influence atherosclerotic plaque phenotype: SMC make up the protective fibrous cap that prevents plaque rupture, but can also transdifferentiate to a destabilizing pro-inflammatory phenotype. We found that LMO7, a scaffolding protein that modulates SMC phenotype, is induced in atherosclerosis. SMC LMO7 deletion produce...

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Literature Corpus work: c4156165-f9aa-5b4f-ba1f-211347ff599e
DOI: 10.21203/rs.3.rs-1359588/v1

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