Article

ADAMTS7 promotes smooth muscle foam cell expansion in atherosclerosis

2024-02-29

Abstract excerpt

<h4>ABSTRACT</h4> Human genetic studies have repeatedly associated ADAMTS7 with atherosclerotic cardiovascular disease. Subsequent investigations in mice demonstrated that ADAMTS7 is proatherogenic and induced in response to vascular injury. However, the cell-specific mechanisms governing ADAMTS7 proatherogenicity remain unclear. To determine which vascular cell types express ADAMTS7 , we interrogated single-ce...

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Literature Corpus work: 7da80a93-8edf-5824-b0ca-d2230d2bf5f5
DOI: 10.1101/2024.02.26.582156

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