Single-Cell Genomics Reveals a Novel Cell State During Smooth Muscle Cell Phenotypic Switching and Potential Therapeutic Targets for Atherosclerosis in Mouse and Human.

doi:10.1161/CIRCULATIONAHA.120.048378

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Article

Single-Cell Genomics Reveals a Novel Cell State During Smooth Muscle Cell Phenotypic Switching and Potential Therapeutic Targets for Atherosclerosis in Mouse and Human.

Circulation - 24 Nov 2020

Pan Huize, Xue Chenyi, Auerbach Benjamin J, Fan Jiaxin, Bashore Alexander C, Cui Jian, Yang Dina Y, Trignano Sarah B, Liu Wen, Shi Jianting, Ihuegbu Chinyere O, Bush Erin C, Worley Jeremy, Vlahos Lukas, Laise Pasquale, Solomon Robert A, Connolly Edward S, Califano Andrea, Sims Peter A, Zhang Hanrui, Li Mingyao, Reilly Muredach P

Abstract excerpt

BACKGROUND: Smooth muscle cells (SMCs) play significant roles in atherosclerosis via phenotypic switching, a pathological process in which SMC dedifferentiation, migration, and transdifferentiation into other cell types. Yet how SMCs contribute to the pathophysiology of atherosclerosis remains elusive. METHODS: To reveal the trajectories of SMC transdifferentiation during atherosclerosis and to identify molecular...

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PMID: 32962412
DOI: 10.1161/CIRCULATIONAHA.120.048378
PMCID: PMC8104264

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