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Article

From smooth to 'breaking bad': vascular smooth muscle cell phenotypic switching at the heart of plaque vulnerability.

Current opinion in lipidology - 1 Oct 2026

Fernando Shevin C, Liu Renjing, Karunakaran Denuja

Abstract excerpt

PURPOSE OF REVIEW: Atherosclerosis persists despite LDL-lowering therapies, highlighting lipid-independent drivers of disease. This review examines vascular smooth muscle cell (VSMC) plasticity as a central determinant of plaque progression and stability and evaluates emerging therapeutic strategies targeting VSMC phenotypic transitions. RECENT FINDINGS: VSMCs exhibit marked phenotypic plasticity, contributing to...

Read the complete abstract on PubMed

Topics

Humans
Kruppel-Like Factor 4
Muscle, Smooth, Vascular
Animals
Plaque, Atherosclerotic
Phenotype

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Myocytes, Smooth Muscle

Atherosclerosis

Source

Identifiers

PMID: 42657523
DOI: 10.1097/MOL.0000000000001056

Genes

KLF4
ACTA2
FAP
LGALS3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 20 Oct 2026.

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