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Article

Cellular communication network factor 2 regulates smooth muscle cell transdifferentiation and lipid accumulation in atherosclerosis.

Cardiovascular research - 31 Dec 2024

Xu Qian, Sun Jisheng, Holden Claire M, Neto Hildebrando Candido Ferreira, Wang Ti, Zhang Chiyuan, Fu Zuli, Joseph Giji, Shi Ruizheng, Wang Jinhu, Leask Andrew, Taylor W Robert, Lin Zhiyong

Abstract excerpt

AIMS: Accruing evidence illustrates an emerging paradigm of dynamic vascular smooth muscle cell (SMC) transdifferentiation during atherosclerosis progression. However, the molecular regulators that govern SMC phenotype diversification remain poorly defined. This study aims to elucidate the functional role and underlying mechanisms of cellular communication network factor 2 (CCN2), a matricellular protein, in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39365752
DOI: 10.1093/cvr/cvae215
PMCID: PMC11687398

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