Article

Selection and structural characterisation of anti-TREM2 scFvs that reduce levels of shed ectodomain

2021-02-08

Abstract excerpt

<h4>Summary</h4> Single point mutations in TREM2, a receptor expressed by microglia in the brain, are associated with an increased risk of neurodegeneration including Alzheimer’s disease. Numerous studies support a role for TREM2 in sensing damaging stimuli and triggering signalling cascades necessary for neuroprotection. Despite its significant role, ligands and regulators of TREM2 activation, and the mechanisms...

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Literature Corpus work: c3d4248a-376d-5411-ba19-bc4cb3e658f6
DOI: 10.1101/2021.02.07.430123

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