Article

Total Chemical Synthesis of Glycosylated TREM2 Ectodomain

2023-04-14

Abstract excerpt

<h4>ABSTRACT</h4> Mutations in a microglia-associated gene TREM2 increase the risk of Alzheimer’s disease. Currently, structural and functional studies of TREM2 mainly rely on recombinant TREM2 proteins expressed from mammalian cells. However, using this method, it is difficult to achieve site-specific labeling. Here we present the total chemical synthesis of the 116 amino-acid TREM2 ectodomain. Rigorous structu...

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Literature Corpus work: 3d565f5d-28a7-5b34-9074-7421b4156b35
DOI: 10.1101/2023.04.14.536909

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