Article
Preparation, crystallization, and preliminary crystallographic analysis of wild-type and mutant human TREM-2 ectodomains linked to neurodegenerative and inflammatory diseases.
Protein expression and purification - 1 Apr 2014
Kober Daniel L, Wanhainen Kelsey M, Johnson Britney M, Randolph David T, Holtzman Michael J, Brett Tom J
Abstract excerpt
TREM-2 (triggering receptor expressed on myeloid cells-2) is an innate immune receptor expressed on dendritic cells, macrophages, osteoclasts, and microglia. Recent genetic studies have reported the occurrence of point mutations in TREM-2 that correlate with a dramatically increased risk for the development of neurodegenerative diseases, including Alzheimer's disease, frontotemporal dementia, and Parkinson's...
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